The National Comprehensive Cancer Network (NCCN v1.2020) guidelines recommend referral to a cancer genetics professional for an individual with one or more of the following:

AFFECTED WITH PROSTATE CANCER

  • Metastatic or intraductal prostate cancer at any age
  • High-grade (Gleason score of 7 or greater) prostate cancer with:
    • Ashkenazi Jewish ancestry; or
    • one or more close relative with breast cancer at or before age 50 or ovarian, pancreatic, or metastatic or intraductal prostate cancer at any age; or
    • two or more close relatives with breast or prostate cancer (any grade) at any age

FAMILY HISTORY OF PROSTATE CANCER

  • A first- or second- degree relative with metastatic or intraductal prostate cancer at any age
  • A first- or second-degree relative with high-grade (Gleason score of 7 or greater) prostate cancer with:
    • Ashkenazi Jewish ancestry; or
    • one or more close relative with breast cancer at or before age 50 or ovarian, pancreatic, or metastatic or intraductal prostate cancer at any age; or
    • two or more close relatives with breast or prostate cancer (any grade) at any age

*Referral is also clinically indicated for individuals meeting criteria but with previous limited testing (eg, single gene and/or absent deletion duplication analysis) interested in pursuing multi-gene testing

CONDITIONS TO CONSIDER: