The National Comprehensive Cancer Network (NCCN v4.2019) guidelines recommend referral to a cancer genetics professional for an individual with one or more of the following:

AFFECTED WITH GASTRIC CANCER

  • An individual affected with gastric cancer before age 40
  • An individual affected with gastric cancer before age 50 who had one first- or second-degree relative affected with gastric cancer
  • An individual affected with gastric cancer at any age who has 2 or more first- or second-degree relatives affected with gastric cancer
  • An individual affected with gastric cancer and breast cancer with one diagnosis before age 50
  • An individual affected with gastric cancer at any age and a family history of breast cancer in a first- or second-degree relative diagnosed before age 50
  • An individual affected with gastric cancer at any age and family history of juvenile polyps or gastrointestinal polyposis
  • An individual affected with gastric cancer at any age and family history of cancers associated with Lynch syndrome (colorectal, endometrial, small bowel, or urinary tract cancer)

FAMILY HISTORY OF GASTRIC CANCER

  • Known pathogenic variant in a gastric cancer susceptibility gene in a close relative
  • Gastric cancer in one first- or second-degree relative who was diagnosed before age 40
  • Gastric cancer in two first- or second-degree relative with one diagnosis before age 50
  • Gastric cancer in three first- or second-degree relatives independent of age
  • Gastric cancer and breast cancer in one patient with one diagnosis before age 50, juvenile polyps, or gastrointestinal polyposis in a close relative

CONDITIONS TO CONSIDER: